Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections

One of the major complications associated with implantation biomedical devices regardless their function is biomaterial-associated infection. Infections are generally initiated by opportunistic bacterial colonization and biofilm development on surface implanted biomaterials, rendering infection impervious to host defenses antimicrobials. Moreover, around soft tissues also has a significant role in infections. It well-documented that nature an implant influenced design composition biomaterial, environment, clinical procedure, patient hygiene. Herein, we explore adhesion mechanisms bacteria biomaterials review systematic antimicrobial strategies reduce contamination underlying using Staphylococcus aureus as model pathogen. Also, discuss preventive therapeutic explain future perspectives for nanoscience-based engineering surfaces, including nanostructure surface, microbe–surface interactions, synthetic nanostructured dynamic surfaces antifouling agents, coated properties (polymer coating, release active coating).